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TRAIL Trial - Cancer in Kids @ RCH - CIKA

The TRAIL Trial Project

TRAIL is the acronym for "TNF-related apoptosis inducing ligand". CIKA commenced funding this project in 2005. Its aim was to establish whether TRAIL is effective in treating solid tumours.

The project was described in the first CIKA newsletter for 2007 when CIKA vice-president, Ellen Webb, provided this report from Christine Hawkins from the TRAIL project.

“Largely as a consequence of the CIKA funded TRAIL project, the Children’s Cancer Centre has comprehensively re-vamped the way tumour samples are processed, for both research and diagnostic purposes.

This new process will enable us to further pursue in-vitro sensitivity testing for solid tumours - analysing sensitivity to TRAIL as well as other new agents.

As you’ll understand, development of the new operating procedures was very time-consuming and involved. We had to get surgeons, pathologists, oncologists, researchers, ethics committee etc all on board, trained and organised.

While doing that, we’ve been researching TRAIL sensitivity and signalling in both adult gliomas and paediatric leukaemias. I know this isn’t an area CIKA is directly concerned with, but I mention it because we’re hoping to be able to re-start the paediatric solid tumor TRAIL line of enquiry soon.

When we do, we’ll be able to take advantage of some new techniques we’ve developed while examining those other tumor types.”